Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity in intravenous immunoglobulin as a potential therapeutic against emerging influenza viruses

S Jegaskanda; K Vandenberg; KL Laurie; L Loh; M Kramski; WR Winnall; K Kedzierska; S Rockman; SJ Kent

Journal article

Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity in intravenous immunoglobulin as a potential therapeutic against emerging influenza viruses

S Jegaskanda, K Vandenberg, KL Laurie, L Loh, M Kramski, WR Winnall, K Kedzierska, S Rockman, SJ Kent

Journal of Infectious Diseases | Published : 2014

DOI: 10.1093/infdis/jiu334

Abstract

Background. Intravenous immunoglobulin (IVIG) is a purified pool of human antibodies from thousands of donors that is used to prevent or treat primary immune deficiency, several infectious diseases, and autoimmune diseases. The antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) against heterologous influenza strains may be present in IVIG preparations. Methods. We tested 8 IVIG preparations prior to the 2009 H1N1 swine-origin influenza pandemic and 10 IVIG preparations made after 2010 for their ability to mediate influenza-specific ADCC. Results. ADCC mediating antibodies to A(H1N1)pdm09 hemagglutinin (HA) and neuraminidase (NA) were detected in IVIG preparations prior t..

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University of Melbourne Researchers

Liyen Loh Author

Katherine Kedzierska Author

Steven Rockman Author

Stephen Kent Author

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Australian National Health and Medical Research Council (NHMRC) awards 628331, 1023294, and 510488. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.